Talk:A one percent difference in chimpanzee-human DNA is huge, given that mice and humans share 98% of their DNA
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Do we have any source or reference for the location of mouse-human DNA sequence homology?--Doddy 00:19, 21 April 2007 (BST)
I don’t really know because i Didn’t make this article.--Fang 23 00:21, 21 April 2007 (BST)
- I really doubt that most of our similarities with mice are on the junk DNA. We do after all share almost all of our anatomy, cell structure and proteins with mice, so I think most of the homology would be in coding regions. Later today, I'll do a search of PubMed or Web of Science for some articles or reviews on this issue.--Doddy 03:21, 21 April 2007 (BST)
The interesting question is: how are those percentages computed? The normal numbers are 2% difference for human-chimp, 4% for human-orang, 5% for human-gibbon. I guess the 2% for human-mouse are a number computed in a totally different way, like "you share 50% of your genes with your mother but 98% with a chimp". --tk 12:31, 2 May 2007 (BST)
- The 98% similarity (I've also heard 99%) between human and mouse DNA refer to counterpart genes (i.e. with the same function), not sequence identity. We only have about 80% sequence identity with mice. When a creationist tells you that the mouse genome is more similar to the human genome than the chimp genome is (and then cite numbers), they are confusing two different types of similarity: functional equivalence in mice, sequence identity in chimps.Tralhob M 00:54, 22 February 2008 (UTC)
